In patients with relapsing-remitting multiple sclerosis (RRMS), fatigue and lower limb problems may predict the risk of conversion to secondary progressive MS (SPMS).

Results from the study1 were presented at the 2017 annual meeting of the American Academy of Neurology, held from April 22nd to 28th, in Boston, Massachusetts.

It is well known that older age at disease onset, a high frequency of relapses, and male sex contribute to a greater risk for MS disease conversion. In this study, Caila Vaughn, PhD, MPH, of the New York State Multiple Sclerosis Consortium and the State University of New York at Buffalo, and colleagues chose to explore patient-reported outcomes that might be predictive of conversion from RRMS to SPMS.

The study included 155 patients with RRMS (age ≥50 years) with a disease duration of at least 15 years. Analyses to evaluate the predictive value of patient-reported outcomes were performed at study enrollment and 5-year follow-up… [Read More]


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